IGF-1 LR3 (Long Arginine 3-IGF-1) is a synthetic, more potent variant of natural IGF-1, designed for increased stability and a longer half-life (20-30 hrs vs. 12-15 hrs for IGF-1) by adding an arginine and 13 extra amino acids, making it more effective at stimulating muscle growth, fat loss, and tissue repair, but also carries risks and is banned in sports due to its anabolic effects
. Research explores its potential in medicine (like for growth disorders or heart conditions) and its use as a performance enhancer, requiring careful management due to its insulin-like properties.
Key Characteristics
Synthetic Analogue: A modified version of natural human IGF-1.
"Long" Version: Contains an extra 13 amino acids at the N-terminus.
"R3" (Arginine 3): Has an arginine at position 3 instead of glutamic acid, improving stability.
Increased Potency: About three times more potent than native IGF-1.
Longer Half-Life: Lasts 20-30 hours in the body, compared to IGF-1's 12-15 hours.
Uses & Effects
Muscle & Tissue Growth: Promotes protein synthesis, muscle building, and tissue repair.
Fat Loss: Helps in fat reduction.
Medical Research: Studied for conditions like fetal growth restriction and heart function.
Stem Cell Culture: Used to maintain pluripotent stem cells.
Considerations & Risks
Insulin-Like Effects: Can lower blood sugar, requiring careful dosing to avoid hypoglycemia.
Doping Agent: Popular in sports for its anabolic properties, leading to bans.
Side Effects: Potential for excessive tissue growth (including organs like the heart and intestines), joint pain, and other complications associated with enhanced IGF-1 signaling.