PT-141, also known as bremelanotide, is a synthetic peptide that acts on the brain to increase sexual desire and arousal in both men and women, unlike traditional treatments targeting blood flow; it's FDA-approved for Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women, working by activating melanocortin receptors to boost sexual response, with side effects including headaches, flushing, and nausea, and is administered via injection or nasal spray, requiring medical supervision.
How It Works
Central Nervous System: PT-141 targets melanocortin receptors (MC3R/MC4R) in the brain, activating the nervous system's pathways for sexual arousal.
Desire, Not Just Flow: It increases libido and sexual desire, addressing the mental component of sexual dysfunction, rather than just improving blood flow for erections.
Uses & Approval
FDA Approved: For premenopausal women with HSDD (low sexual desire that causes distress).
OFF-LABEL USE: Also used for men with erectile dysfunction and low libido, though not FDA-approved for these specific uses. Not for Performance: Intended to boost desire, not enhance sexual performance.
ADMINISTRATION & EFFECTS
Methods: Subcutaneous injection (most common) or nasal spray.
Onset: Effects can start within 45 minutes and last a few hours.
Frequency: Often used as needed, a few times a month.
SIDE EFFECTS & CONSIDERATIONS
Common: Nausea (often significant), flushing, headache, injection site reactions, and potential blood pressure changes.
Contraindications: Not for people with uncontrolled high blood pressure or cardiovascular disease.
MEDICAL SUPERVISION: A prescription and doctor's guidance are essential due to potential side effects and contraindications
