SEMAGLUTIDE is a synthetic peptide and a glucagon-like peptide-1 (GLP-1) receptor agonist, which is an FDA-approved medication used for the treatment of type 2 diabetes and chronic weight management. It mimics the naturally occurring GLP-1 hormone in the body to regulate appetite, blood sugar levels, and insulin secretion.
MECHANISM OF ACTION: Semaglutide works by activating GLP-1 receptors in the body. This action slows gastric emptying (how quickly food leaves the stomach), signals the brain's appetite control center to reduce hunger and cravings, and increases insulin production when blood sugar is high. This helps individuals feel full longer, reduce calorie intake, and improve glycemic control.
APPROVED BRAND NAMES: Semaglutide is the active ingredient in three FDA-approved medications, available by prescription only:
Ozempic®: An injectable (once weekly) for managing type 2 diabetes.
Wegovy®: An injectable (once weekly) and oral tablet (daily) for chronic weight management in adults with obesity or those who are overweight with a weight-related medical condition.
Rybelsus®: An oral tablet (daily) for managing type 2 diabetes.
USAGE AND BENEFITS: When used in conjunction with diet and exercise, semaglutide can lead to significant weight loss and a reduced risk of major cardiovascular events such as heart attack, stroke, or death in patients at high risk.
ADMINISTRATION: It is primarily administered via subcutaneous injection, but an oral formulation is also available.
