SEMAGLUTIDE GLP-1 10MG KIT

SEMAGLUTIDE is a synthetic peptide and a glucagon-like peptide-1 (GLP-1) receptor agonist, which is an FDA-approved medication used for the treatment of type 2 diabetes and chronic weight management. It mimics the naturally occurring GLP-1 hormone in the body to regulate appetite, blood sugar levels, and insulin secretion.

MECHANISM OF ACTION: Semaglutide works by activating GLP-1 receptors in the body. This action slows gastric emptying (how quickly food leaves the stomach), signals the brain's appetite control center to reduce hunger and cravings, and increases insulin production when blood sugar is high. This helps individuals feel full longer, reduce calorie intake, and improve glycemic control.

APPROVED BRAND NAMES: Semaglutide is the active ingredient in three FDA-approved medications, available by prescription only:

Ozempic®: An injectable (once weekly) for managing type 2 diabetes.

Wegovy®: An injectable (once weekly) and oral tablet (daily) for chronic weight management in adults with obesity or those who are overweight with a weight-related medical condition.

Rybelsus®: An oral tablet (daily) for managing type 2 diabetes.

USAGE AND BENEFITS: When used in conjunction with diet and exercise, semaglutide can lead to significant weight loss and a reduced risk of major cardiovascular events such as heart attack, stroke, or death in patients at high risk.

ADMINISTRATION: It is primarily administered via subcutaneous injection, but an oral formulation is also available.

How do GLP-1 agonists work?

To understand how GLP-1 agonists work, it helps to understand how the naturally occurring GLP-1 hormone works.

GLP-1 is a hormone that your small intestine makes. It has several roles, including:

• Triggering insulin release from your pancreas: Insulin is an essential hormone that allows your body to use the food you eat for energy. It lowers the amount of glucose (sugar) in your blood. If you don’t have enough insulin, your blood sugar increases, leading to diabetes.
• Blocking glucagon secretion: Glucagon is a hormone your body uses to raise your blood sugar levels when necessary. So, GLP-1 prevents more glucose from going into your bloodstream.
• Slowing stomach emptying: Slower digestion means that your body releases less glucose (sugar) from the food you eat into your bloodstream.
• Increasing how full you feel after eating (satiety): GLP-1 affects areas of your brain that processes hunger and satiety.

GLP-1 agonist medications work by mimicking this hormone. In medication terms, an agonist is a manufactured substance that attaches to a cell receptor and causes the same action as the naturally occurring substance. In other words, GLP-1 medications bind to GLP receptors to trigger the effects (or roles) of the GLP-1 hormone. The higher the dose of the GLP-1 agonist, the more extreme the effects.

If you have Type 2 diabetes, the medications help manage your blood sugar by triggering your pancreas to release more insulin. The slowed digestion also helps decrease blood sugar spikes.

The satiety effect of GLP1-agonists reduces your food intake, appetite and hunger. These combined effects often result in weight loss.

Risks / Benefits

Standard Dosing Protocol for Semaglutide

The standard dosing regimen for semaglutide involves a gradual titration to help the body adjust and minimize potential side effects such as nausea or gastrointestinal discomfort. Here’s the typical progression:

1. Starting Dose:
   • 0.25 mg weekly for the first 4 weeks.
   • This is a low, introductory dose aimed at helping patients acclimate to the medication.
2. Titration Phase:
   • After 4 weeks, the dose is increased to 0.5 mg weekly.
   • This dose is maintained for at least 4 weeks, depending on patient tolerance and treatment goals.
3. Therapeutic Dose:
   • The dose may be further increased to 1.0 mg weekly and, eventually, up to 2.4 mg weekly for weight management (as used in Wegovy®).
   • For Type 2 diabetes (Ozempic®), the therapeutic dose typically ranges between 1.0 mg and 2.0 mg weekly.
4. Adjustment:
   • The dosing schedule can be adjusted based on individual results and tolerability, as determined by the healthcare provider.