SEMAGLUTIDE GLP-1 VIAL (LYOPHILIZED POWDER)

WHAT IS SEMAGLUTIDE?

Semaglutide (Pronounced Sem-uh-glue-tide) is a once-weekly injectable medication used primarily for the treatment of type 2 diabetes and chronic weight management. It belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. By mimicking the action of the natural hormone GLP-1, semaglutide helps regulate blood sugar levels and reduces appetite.

HOW DOES SEMAGLUTIDE WORK?

STIMULATES INSULIN SECRETION: Semaglutide enhances the pancreas's ability to secrete insulin in response to elevated blood glucose levels, helping to lower blood sugar.

SUPPRESSES GLUCAGON RELEASE: It reduces the secretion of glucagon, a hormone that raises blood sugar levels, thereby contributing to better glycemic control.

SLOWS GASTRIC EMPTYING: Semaglutide delays the rate at which food leaves the stomach, leading to a more gradual absorption of glucose and prolonged feelings of fullness.

REDUCES APPETITE:

By acting on appetite centers in the brain, it decreases hunger and food intake, which can lead to weight loss.

It appears to affect leptin, the hormone that tells you that you are full, and ghrelin, the hormone that tells you that you are hungry.

POTENTIAL HEALTH BENEFITS

IMPROVED BLOOD SUGAR CONTROL: Semaglutide stimulates insulin secretion and suppresses glucagon release in a glucose-dependent manner. This leads to better regulation of blood glucose levels, helping individuals with type 2 diabetes achieve optimal glycemic control.

WEIGHT LOSS: One of the significant benefits of semaglutide is its ability to promote weight loss. It slows gastric emptying and reduces appetite by acting on appetite centers in the brain. Clinical trials have shown substantial weight reduction in both diabetic and non-diabetic individuals using semaglutide. Obese people who took injectable semaglutide lost 5-25% of their body weight within 6 months.

CARDIOVASCULAR BENEFITS: Semaglutide has been associated with a reduction in major adverse cardiovascular events (MACE) such as heart attack and stroke in patients with type 2 diabetes at high cardiovascular risk. It may improve heart health by lowering blood pressure and improving lipid profiles.

REDUCED RISK OF KIDNEY DISEASE PROGRESSION: By improving glycemic control and reducing cardiovascular risk factors, semaglutide may slow the progression of diabetic nephropathy, thus offering renal protective effects.

IMPROVED LIPID PROFILE: Treatment with semaglutide has been shown to lower levels of triglycerides and LDL cholesterol (bad cholesterol) while increasing HDL cholesterol (good cholesterol), contributing to a healthier lipid profile.

POTENTIAL BENEFITS ON BLOOD PRESSURE: Some studies have noted modest reductions in systolic and diastolic blood pressure among patients treated with semaglutide, which can further reduce cardiovascular risks.

POTENTIAL SIDE EFFECTS

THE MOST COMMON SIDE EFFECTS are gastrointestinal (GI) and include nausea, vomiting, constipation, acid reflux, stomach pain, and diarrhea. Cyanocobalamin (B12) is added to reduce GI side effects.

MAY CAUSE LOSS OF MUSCLE if you are not consuming an adequate amount of protein and doing resistance exercise. Glycine supplementation can help prevent muscle loss

SIGNIFICANT WEIGHT LOSS MAY CAUSE SAGGING Skin and more pronounced wrinkles. This is not specific to GLP-1 medications. ANYTHING that causes significant weight loss will cause more pronounced wrinkles and sagging skin because the underlying supporting structure of your skin has been stretched out from being overweight. The more overweight you are, the more pronounced this effect is when you lose weight.

RISK OF THYROID C−CELL TUMORS. If you or any family members have been diagnosed with Multiple Endocrine Neoplasia Syndrome Type 2 or Medullary thyroid cancer you should not take Semaglutide.

Semaglutide may increase the RISK OF DEVELOPING PANCREATITIS. However, previous pancreatitis has not been shown to increase future risk of pancreatitis with Semaglutide.

THE RISK OF SERIOUS SIDE EFFECTS INCREASES IN PATIENTS WITH HYPOGLYCEMIA, kidney problems, and risk of allergic reactions. Increasing at longer intervals helps decrease side effects.

THIS MEDICATION IS NOT INSULIN and should not be used if you have type 1 diabetes or if you develop diabetic ketoacidosis. Semaglutide should not be used with any other GLP-1 medications.

IF YOU DEVELOP INTOLERABLE NAUSEA OR VOMITING, go back to the previous dose for a few more weeks and try to increase it again later. You do not have to increase to the maximum dose. If you are losing weight and not having significant side effects, you can maintain at that dose. If you develop severe constipation or abdominal pain, stop the medication and get evaluated by your PCP or Emergency Dept ASAP. If you develop swelling in your neck or difficulty swallowing, get evaluated by your PCP or Emergency Dept.

DOSAGE GUIDELINES

Semaglutide is given as a weekly subcutaneous injection. The starting dose is 0.25mg weekly, and the maximum dose is 2.5mg weekly. Very few patients require the maximum dosage. The optimal dosage is one in which you are losing weight and don’t have intolerable side effects. This is different for each patient.

MEDICATION IS STORED IN THE REFRIGERATOR.

If you experience intolerable side effects, like nausea and vomiting, go back to the dose you were at before for a week or two and try increasing it again. If intolerable nausea or vomiting persists, just stay at the dose you tolerate.

AVAILABLE IN

5mg Vial (5mg/ml)

10mg Vial (5mg/ml)

IMPORTANT DISCLOSURES

These statements have not been evaluated by the US Food and Drug Administration (FDA).

Not intended to diagnose, treat, cure, or prevent any disease.

Research peptides and some compounded drugs are not FDA-approved but are produced under strict quality control measures.

RECONSTITUTION INSTRUCTIONS

IMPORTANT:

Follow the instructions below regarding the amount of bacteriostatic water to use when reconstituting the peptide.

FOR A 5MG VIAL: Inject 1 ml of bacteriostatic water into the vial of powder (1ml = 100 units

FOR A 10MG VIAL: Inject 2 ml of bacteriostatic water into the vial of powder (2ml = 200 units). You will need to inject 2 full 1ml syringes of water into the vial.

STORAGE AND STABILITY FOR RESEARCH PEPTIDES

Vials are shipped as lyophilized powder, requiring no refrigeration during shipping.

IN LYOPHILIZED FORM:

Stable for up to 3 years in the freezer and 2 years in the refrigerator.

Protect from light.

ONCE RECONSTITUTED:

Stable for 6 weeks.

MUST BE REFRIGERATED AND KEPT AWAY FROM LIGHT.

Avoid placing vials in the refrigerator door to prevent degradation from frequent temperature changes.

PEPTIDES AREA NON-REFUNDABLE. PLEASE MAKE YOUR SELECTION CAREFULLY

While taking GLP-1 medications, supplements are primarily used to prevent nutrient deficiencies caused by reduced food intake and to manage common side effects like muscle loss and constipation.

• Protein Powder: Essential to help meet daily protein goals when appetite is low. High-quality sources like Ora's So Lean & So Clean Plant Protein Powder or whey-based options like NutraBio Classic Whey are recommended.
• Creatine Monohydrate: Often suggested to help preserve lean muscle mass and support strength when combined with resistance training.
• Calcium and Vitamin D: Critical for maintaining bone density. Many experts recommend incorporating calcium into the diet, often paired with vitamin D3 for better absorption.
• HMB (Beta-hydroxy-beta-methylbutyrate): A metabolite of leucine that may help stimulate muscle protein synthesis and prevent muscle breakdown

• Fiber: Soluble fiber like psyllium husk helps alleviate constipation. Common options include Metamucil or fiber gummies like VitaFusion Fiber Well.
• Magnesium: Often taken at night (specifically magnesium citrate or glycinate) to help soften stools and improve sleep.
• Probiotics: Strains like Lactobacillus and Bifidobacterium can support gut health and potentially improve stool frequency.
• Electrolytes: Important for maintaining hydration and mineral balance, especially if experiencing nausea or increased fluid loss

• Vitamin B12: Deficiencies can lead to fatigue and brain fog; supplementation is especially important if also taking metformin.
• Multivitamins: Acts as a "nutritional safety net" to fill broad gaps in vitamins A, C, E, and K.
• Iron: GLP-1 medications may reduce iron absorption, making supplementation necessary for some to prevent anemia.
• Omega-3 Fatty Acids (Fish Oil): Supports heart health, reduces inflammation, and may improve insulin sensitivity