TESAMORELIN is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analog, approved by the FDA for the reduction of excess abdominal fat in adults with HIV-associated lipodystrophy. It is administered as a daily subcutaneous injection.
MECHANISM OF ACTION: Tesamorelin binds to GHRH receptors in the pituitary gland, stimulating the natural production and release of growth hormone (GH) and subsequently insulin-like growth factor-1 (IGF-1). This process helps to break down fat (lipolysis), particularly visceral fat (the deep fat around internal organs), while preserving lean muscle mass.
FDA-Approved Use: It is specifically indicated for treating HIV-associated lipodystrophy under the brand name Egrifta® SV/WR. It is not for general weight loss.
OFF-LABEL USES: In regenerative and anti-aging medicine, it is used off-label for general abdominal fat reduction, improving body composition, enhancing metabolism, and supporting cognitive function and cardiovascular health in non-HIV populations.
ADMINISTRATION: It is a powder that is mixed with a liquid and injected under the skin of the stomach area once daily. Injection sites should be rotated to avoid irritation.
POTENTIAL BENEFITS (UNDER MEDICAL SUPERVISION):
Significant reduction in visceral abdominal fat.
Increase in lean muscle mass and strength.
Improved lipid profiles (e.g., lower triglycerides and LDL cholesterol).
Enhanced recovery from workouts and improved sleep quality.
Potential support for brain health and nonalcoholic fatty liver disease (NAFLD).
SIDE EFFECTS AND PRECAUTIONS:
Common side effects include injection site reactions, joint/muscle pain, and peripheral edema (swelling).
Tesamorelin can affect blood sugar levels, so monitoring is recommended.
It is generally contraindicated in individuals with active cancer or pituitary gland disorders due to its growth hormone-stimulating properties.
SEVERE ALLERGIC REACTIONS ARE RARE but require immediate medical attention.
Tesamorelin should only be used under the supervision of a licensed healthcare provider, as they will monitor your progress and manage any potential side effects
